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Bioinformatics Technology ppt
What is Bioinformatics?
Bioinformatics involves the integration of computers, software tools, and databases in an effort to address biological questions.
Bioinformatics, Computational biology & Supercomputing
Bioinformatics applies principles of information
sciences and technologies to make the vast, diverse, and complex life sciences data more understandable and useful.
Computational biology uses mathematical and
computational approaches to address theoretical and experimental questions in biology.
Supercomputing is the use supercomputers in biology.
Pioneer of Bioinformatics?
Dr. Margaret Oakley Dayhoff
Global Bio-Informatics Market – 1.2bn In 2004
Overall Market Size Projected to reach USD 1.7 bn by 2006
Indian Bioinformatics Market has touched USD22 Million in 2004
Indian Bioinformatics is growing at the rate of 40% per annum
MK Univ., Madurai
Univ. of Pune
IIT, , Delhi
Components of Bioinformatics?
Biological Data Hardware Software
• Biology: a data-rich science , the need for
storing and communicating large datasets has grown tremendously.
• Type of data
nucleotide sequences protein sequences
proteins sequence patterns or motifs macromolecular 3D structure gene expression data metabolic pathways
Compute Clusters ( collection of computers that are highly
interconnected via a high-speed network)
Login Servers (provide a single secure login point for access to
all other machines)
File Servers (TB of space and is reserved for projects and
database hosting) Backup Servers Web Servers
Master & Fail-over Servers (for user authorization &
Memory Servers (purpose is to run programs which require
huge amounts of memory)
Linux: Debian and Ubuntu UNIX: Solaris and IRIX
Bioinformatics Software: used for visualization and
analysis of biological information.
ChemGenome 2.0 PreDDICTA Bhageerath Sanjeevini
Trend of OS used
Primary or derived data
Primary databases: experimental results directly into
Secondary databases: results of analysis of primary databases Aggregate of many databases
Links to other data items Combination of data Consolidation of data
Relational database (SQL)
Object-oriented database (e.g. CORBA, XML)
There are two main functions of biological databases: 1.Make biological data available to scientists.
As much as possible of a particular type of information should be available in one single place (book, site, database). Published data may be difficult to find or access, and collecting it from the literature is very time-consuming. And not all data is actually published explicitly in an article (genome sequences!).
2.To make biological data available in computer-readable form.
Since analysis of biological data almost always involves computers, having the data in computer-readable form (rather than printed on paper) is a necessary first step.
One of the first biological sequence databases was probably the book “Atlas of Protein Sequences and Structures” by Margaret Dayhoff and colleagues, first published in 1965. It contained the protein sequences determined at the time, and new editions of the book were published well into the 1970s. Its data became the foundation for the PIR database (Protein Information
SCFBio, IIT, New Delhi
Primary (Questionnaires & Interview) Secondary (Internet & Books)
Most of the software are developed in what field?
Protein structure prediction
0 1 2 3 4 5 6
Has software made bioinformatics easier?
Has supercomputing made research and development in biology easier?
yes no can’t say
Have you heard about Super
Computing Facility for Bio-informatics & Computational Biology?
Have you bought any software by SCFBCB?
• Drug discovery is a new area in which India is developing with
maximum research going on in this field.
• As per our survey, India is economical in terms of
implementation. Here software development is cost effective. Initial cost will be high but once the development cost will be recovered, it will be proved as a very cost effective technology. Hence it can be concluded that in our country, there is great potential for the software development.
• Scientists also believe that this technology has helped a lot in
bioinformatics. The development in IT sector is contributing in development of Bioinformatics to a great extent.
MORE INVESTMENT SHOULD TAKE PLACE IN
RESEARCH IN BIOINFORMATICS AND IT
DEVELOPMENT SO THAT WE CAN HAVE BETTER SOFTWARES TECHNOLOGY.
NO DOUBT THE COST OF IMPLEMENTATION IS
REASONABLE IN INDIA BUT COST OF
DEVELOPMENT IS HIGH WHICH PULLS BACK THE R&D IN THIS SECTOR.HENCE STEPS SHOULD BE TAKEN TO BRING DOWN THE COST OF DEVELOPMENT AS WELL.
Last Updated on 15 May 2016